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human lung cancer tissue arrays lac-1403  (Servicebio Inc)

 
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    Servicebio Inc human lung cancer tissue arrays lac-1403
    YTHDC2 gene and protein expression is downregulated in patients with <t>lung</t> <t>cancer</t> from The Cancer Gene Atlas, Gene Expression Omnibus and <t>Human</t> Protein Atlas databases, as well as in CS-exposed cells. (A) Differential analysis of YTHDC2 mRNA expression in lung cancer tissues based on the Gene Expression Profiling Interactive Analysis tool. * P<0.05 vs. normal tissues. Differential analysis of YTHDC2 mRNA expression in lung cancer tissues from (B) GSE32665 and (C) GSE19188 datasets. (D) Representative IHC images showed that YTHDC2 staining was found in the cell cytoplasm in lung cancer and normal lung tissues. High expression of YTHDC2 could be found in adjacent normal tissues, while its expression was decreased in the majority of lung cancer tissues. (E) Differential analysis of YTHDC2 staining positive ratio quantitated by IHC Profiler in lung cancer <t>tissue</t> <t>arrays.</t> YTHDC2 staining positive ratio in lung cancer tissues with different (F) maximum diameter, (G) pathological stage and (H) invasion depth. (I) Relative mRNA expression level of YTHDC2 in CS-exposed cells (S10, S20 and S30) and normal BEAS-2B cells. Western blot analysis (J) and quantitative results (K) of YTHDC2 protein expression in CS-exposed cells (S10, S20 and S30) and normal BEAS-2B cells. S10, S20 and S30 represent BEAS-2B cells exposed to CS for 10, 20 and 30 passages, respectively. **P<0.01 vs. normal BEAS-2B cells. IHC, immunohistochemistry; YTHDC2, YTH domain containing 2; CS, cigarette smoke.
    Human Lung Cancer Tissue Arrays Lac 1403, supplied by Servicebio Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/human+lung+cancer+tissue+arrays+lac-1403/pmc08315025-41-0-14?v=Servicebio+Inc
    Average 90 stars, based on 1 article reviews
    human lung cancer tissue arrays lac-1403 - by Bioz Stars, 2026-07
    90/100 stars

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    1) Product Images from "Downregulation of m 6 A Reader YTHDC2 Promotes the Proliferation and Migration of Malignant Lung Cells via CYLD/NF-κB Pathway"

    Article Title: Downregulation of m 6 A Reader YTHDC2 Promotes the Proliferation and Migration of Malignant Lung Cells via CYLD/NF-κB Pathway

    Journal: International Journal of Biological Sciences

    doi: 10.7150/ijbs.58514

    YTHDC2 gene and protein expression is downregulated in patients with lung cancer from The Cancer Gene Atlas, Gene Expression Omnibus and Human Protein Atlas databases, as well as in CS-exposed cells. (A) Differential analysis of YTHDC2 mRNA expression in lung cancer tissues based on the Gene Expression Profiling Interactive Analysis tool. * P<0.05 vs. normal tissues. Differential analysis of YTHDC2 mRNA expression in lung cancer tissues from (B) GSE32665 and (C) GSE19188 datasets. (D) Representative IHC images showed that YTHDC2 staining was found in the cell cytoplasm in lung cancer and normal lung tissues. High expression of YTHDC2 could be found in adjacent normal tissues, while its expression was decreased in the majority of lung cancer tissues. (E) Differential analysis of YTHDC2 staining positive ratio quantitated by IHC Profiler in lung cancer tissue arrays. YTHDC2 staining positive ratio in lung cancer tissues with different (F) maximum diameter, (G) pathological stage and (H) invasion depth. (I) Relative mRNA expression level of YTHDC2 in CS-exposed cells (S10, S20 and S30) and normal BEAS-2B cells. Western blot analysis (J) and quantitative results (K) of YTHDC2 protein expression in CS-exposed cells (S10, S20 and S30) and normal BEAS-2B cells. S10, S20 and S30 represent BEAS-2B cells exposed to CS for 10, 20 and 30 passages, respectively. **P<0.01 vs. normal BEAS-2B cells. IHC, immunohistochemistry; YTHDC2, YTH domain containing 2; CS, cigarette smoke.
    Figure Legend Snippet: YTHDC2 gene and protein expression is downregulated in patients with lung cancer from The Cancer Gene Atlas, Gene Expression Omnibus and Human Protein Atlas databases, as well as in CS-exposed cells. (A) Differential analysis of YTHDC2 mRNA expression in lung cancer tissues based on the Gene Expression Profiling Interactive Analysis tool. * P<0.05 vs. normal tissues. Differential analysis of YTHDC2 mRNA expression in lung cancer tissues from (B) GSE32665 and (C) GSE19188 datasets. (D) Representative IHC images showed that YTHDC2 staining was found in the cell cytoplasm in lung cancer and normal lung tissues. High expression of YTHDC2 could be found in adjacent normal tissues, while its expression was decreased in the majority of lung cancer tissues. (E) Differential analysis of YTHDC2 staining positive ratio quantitated by IHC Profiler in lung cancer tissue arrays. YTHDC2 staining positive ratio in lung cancer tissues with different (F) maximum diameter, (G) pathological stage and (H) invasion depth. (I) Relative mRNA expression level of YTHDC2 in CS-exposed cells (S10, S20 and S30) and normal BEAS-2B cells. Western blot analysis (J) and quantitative results (K) of YTHDC2 protein expression in CS-exposed cells (S10, S20 and S30) and normal BEAS-2B cells. S10, S20 and S30 represent BEAS-2B cells exposed to CS for 10, 20 and 30 passages, respectively. **P<0.01 vs. normal BEAS-2B cells. IHC, immunohistochemistry; YTHDC2, YTH domain containing 2; CS, cigarette smoke.

    Techniques Used: Expressing, Gene Expression, Staining, Western Blot, Immunohistochemistry

    YTHDC2 mRNA expression was regulated by gene amplification. Distribution of patients with (A) LUAD and (D) LUSC with different YTHDC2 amplification status. YTHDC2 mRNA expression in (B) LUAD and (E) LUSC tissues with different YTHDC2 amplification status. Different letters (a, b, c and d) represent statistically significant group differences. Pearson's correlation analysis revealed a significant positive correlation between YTHDC2 mRNA expression and copy numbers in (C) LUAD and (F) LUSC. The line represents linear regression of data (LUAD: y=1.065x+9.177, R 2 =0.385; LUSC: y=0.965x+9.318, R 2 =0.198). (G) The Oncomine datasets for the corresponding YTHDC2 copy numbers in lung cancer were obtained with a threshold P=0.001 and ≥2 fold-change. The data in the graphic show significant downregulation (blue column) of YTHDC2 copy numbers in lung cancer versus normal tissue. The intensity of the blue color represents the respective levels of YTHDC2 copy number. (H) Copy number variation in LUAD samples with different smoking histories. Different letters (a, b, c and d) represent statistically significant group differences. (I) Copy number variation of YTHDC2 in BEAS-2B cells and cigarette smoke-exposed cells (grey block), as well as in two lung cancer cell lines (black block). The dotted line (copy number = 2) represents the copy number of the reference gene RNase P. * P<0.05, ** P<0.01 vs. BEAS-2B cells. YTHDC2, YTH domain containing 2; LUSC, lung squamous cell carcinoma; LUAD , lung adenocarcinoma.
    Figure Legend Snippet: YTHDC2 mRNA expression was regulated by gene amplification. Distribution of patients with (A) LUAD and (D) LUSC with different YTHDC2 amplification status. YTHDC2 mRNA expression in (B) LUAD and (E) LUSC tissues with different YTHDC2 amplification status. Different letters (a, b, c and d) represent statistically significant group differences. Pearson's correlation analysis revealed a significant positive correlation between YTHDC2 mRNA expression and copy numbers in (C) LUAD and (F) LUSC. The line represents linear regression of data (LUAD: y=1.065x+9.177, R 2 =0.385; LUSC: y=0.965x+9.318, R 2 =0.198). (G) The Oncomine datasets for the corresponding YTHDC2 copy numbers in lung cancer were obtained with a threshold P=0.001 and ≥2 fold-change. The data in the graphic show significant downregulation (blue column) of YTHDC2 copy numbers in lung cancer versus normal tissue. The intensity of the blue color represents the respective levels of YTHDC2 copy number. (H) Copy number variation in LUAD samples with different smoking histories. Different letters (a, b, c and d) represent statistically significant group differences. (I) Copy number variation of YTHDC2 in BEAS-2B cells and cigarette smoke-exposed cells (grey block), as well as in two lung cancer cell lines (black block). The dotted line (copy number = 2) represents the copy number of the reference gene RNase P. * P<0.05, ** P<0.01 vs. BEAS-2B cells. YTHDC2, YTH domain containing 2; LUSC, lung squamous cell carcinoma; LUAD , lung adenocarcinoma.

    Techniques Used: Expressing, Amplification, Blocking Assay



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    human lung cancer tissue arrays lac-1403  (Servicebio Inc)
    90
    Servicebio Inc human lung cancer tissue arrays lac-1403
    YTHDC2 gene and protein expression is downregulated in patients with <t>lung</t> <t>cancer</t> from The Cancer Gene Atlas, Gene Expression Omnibus and <t>Human</t> Protein Atlas databases, as well as in CS-exposed cells. (A) Differential analysis of YTHDC2 mRNA expression in lung cancer tissues based on the Gene Expression Profiling Interactive Analysis tool. * P<0.05 vs. normal tissues. Differential analysis of YTHDC2 mRNA expression in lung cancer tissues from (B) GSE32665 and (C) GSE19188 datasets. (D) Representative IHC images showed that YTHDC2 staining was found in the cell cytoplasm in lung cancer and normal lung tissues. High expression of YTHDC2 could be found in adjacent normal tissues, while its expression was decreased in the majority of lung cancer tissues. (E) Differential analysis of YTHDC2 staining positive ratio quantitated by IHC Profiler in lung cancer <t>tissue</t> <t>arrays.</t> YTHDC2 staining positive ratio in lung cancer tissues with different (F) maximum diameter, (G) pathological stage and (H) invasion depth. (I) Relative mRNA expression level of YTHDC2 in CS-exposed cells (S10, S20 and S30) and normal BEAS-2B cells. Western blot analysis (J) and quantitative results (K) of YTHDC2 protein expression in CS-exposed cells (S10, S20 and S30) and normal BEAS-2B cells. S10, S20 and S30 represent BEAS-2B cells exposed to CS for 10, 20 and 30 passages, respectively. **P<0.01 vs. normal BEAS-2B cells. IHC, immunohistochemistry; YTHDC2, YTH domain containing 2; CS, cigarette smoke.
    Human Lung Cancer Tissue Arrays Lac 1403, supplied by Servicebio Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/human+lung+cancer+tissue+arrays+lac-1403/pmc08315025-41-0-14?v=Servicebio+Inc
    Average 90 stars, based on 1 article reviews
    human lung cancer tissue arrays lac-1403 - by Bioz Stars, 2026-07
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    YTHDC2 gene and protein expression is downregulated in patients with lung cancer from The Cancer Gene Atlas, Gene Expression Omnibus and Human Protein Atlas databases, as well as in CS-exposed cells. (A) Differential analysis of YTHDC2 mRNA expression in lung cancer tissues based on the Gene Expression Profiling Interactive Analysis tool. * P<0.05 vs. normal tissues. Differential analysis of YTHDC2 mRNA expression in lung cancer tissues from (B) GSE32665 and (C) GSE19188 datasets. (D) Representative IHC images showed that YTHDC2 staining was found in the cell cytoplasm in lung cancer and normal lung tissues. High expression of YTHDC2 could be found in adjacent normal tissues, while its expression was decreased in the majority of lung cancer tissues. (E) Differential analysis of YTHDC2 staining positive ratio quantitated by IHC Profiler in lung cancer tissue arrays. YTHDC2 staining positive ratio in lung cancer tissues with different (F) maximum diameter, (G) pathological stage and (H) invasion depth. (I) Relative mRNA expression level of YTHDC2 in CS-exposed cells (S10, S20 and S30) and normal BEAS-2B cells. Western blot analysis (J) and quantitative results (K) of YTHDC2 protein expression in CS-exposed cells (S10, S20 and S30) and normal BEAS-2B cells. S10, S20 and S30 represent BEAS-2B cells exposed to CS for 10, 20 and 30 passages, respectively. **P<0.01 vs. normal BEAS-2B cells. IHC, immunohistochemistry; YTHDC2, YTH domain containing 2; CS, cigarette smoke.

    Journal: International Journal of Biological Sciences

    Article Title: Downregulation of m 6 A Reader YTHDC2 Promotes the Proliferation and Migration of Malignant Lung Cells via CYLD/NF-κB Pathway

    doi: 10.7150/ijbs.58514

    Figure Lengend Snippet: YTHDC2 gene and protein expression is downregulated in patients with lung cancer from The Cancer Gene Atlas, Gene Expression Omnibus and Human Protein Atlas databases, as well as in CS-exposed cells. (A) Differential analysis of YTHDC2 mRNA expression in lung cancer tissues based on the Gene Expression Profiling Interactive Analysis tool. * P<0.05 vs. normal tissues. Differential analysis of YTHDC2 mRNA expression in lung cancer tissues from (B) GSE32665 and (C) GSE19188 datasets. (D) Representative IHC images showed that YTHDC2 staining was found in the cell cytoplasm in lung cancer and normal lung tissues. High expression of YTHDC2 could be found in adjacent normal tissues, while its expression was decreased in the majority of lung cancer tissues. (E) Differential analysis of YTHDC2 staining positive ratio quantitated by IHC Profiler in lung cancer tissue arrays. YTHDC2 staining positive ratio in lung cancer tissues with different (F) maximum diameter, (G) pathological stage and (H) invasion depth. (I) Relative mRNA expression level of YTHDC2 in CS-exposed cells (S10, S20 and S30) and normal BEAS-2B cells. Western blot analysis (J) and quantitative results (K) of YTHDC2 protein expression in CS-exposed cells (S10, S20 and S30) and normal BEAS-2B cells. S10, S20 and S30 represent BEAS-2B cells exposed to CS for 10, 20 and 30 passages, respectively. **P<0.01 vs. normal BEAS-2B cells. IHC, immunohistochemistry; YTHDC2, YTH domain containing 2; CS, cigarette smoke.

    Article Snippet: Human lung cancer tissue arrays (cat. no. LAC-1402 and LAC-1403) were purchased from Wuhan Servicebio Technology Co., Ltd.

    Techniques: Expressing, Gene Expression, Staining, Western Blot, Immunohistochemistry

    YTHDC2 mRNA expression was regulated by gene amplification. Distribution of patients with (A) LUAD and (D) LUSC with different YTHDC2 amplification status. YTHDC2 mRNA expression in (B) LUAD and (E) LUSC tissues with different YTHDC2 amplification status. Different letters (a, b, c and d) represent statistically significant group differences. Pearson's correlation analysis revealed a significant positive correlation between YTHDC2 mRNA expression and copy numbers in (C) LUAD and (F) LUSC. The line represents linear regression of data (LUAD: y=1.065x+9.177, R 2 =0.385; LUSC: y=0.965x+9.318, R 2 =0.198). (G) The Oncomine datasets for the corresponding YTHDC2 copy numbers in lung cancer were obtained with a threshold P=0.001 and ≥2 fold-change. The data in the graphic show significant downregulation (blue column) of YTHDC2 copy numbers in lung cancer versus normal tissue. The intensity of the blue color represents the respective levels of YTHDC2 copy number. (H) Copy number variation in LUAD samples with different smoking histories. Different letters (a, b, c and d) represent statistically significant group differences. (I) Copy number variation of YTHDC2 in BEAS-2B cells and cigarette smoke-exposed cells (grey block), as well as in two lung cancer cell lines (black block). The dotted line (copy number = 2) represents the copy number of the reference gene RNase P. * P<0.05, ** P<0.01 vs. BEAS-2B cells. YTHDC2, YTH domain containing 2; LUSC, lung squamous cell carcinoma; LUAD , lung adenocarcinoma.

    Journal: International Journal of Biological Sciences

    Article Title: Downregulation of m 6 A Reader YTHDC2 Promotes the Proliferation and Migration of Malignant Lung Cells via CYLD/NF-κB Pathway

    doi: 10.7150/ijbs.58514

    Figure Lengend Snippet: YTHDC2 mRNA expression was regulated by gene amplification. Distribution of patients with (A) LUAD and (D) LUSC with different YTHDC2 amplification status. YTHDC2 mRNA expression in (B) LUAD and (E) LUSC tissues with different YTHDC2 amplification status. Different letters (a, b, c and d) represent statistically significant group differences. Pearson's correlation analysis revealed a significant positive correlation between YTHDC2 mRNA expression and copy numbers in (C) LUAD and (F) LUSC. The line represents linear regression of data (LUAD: y=1.065x+9.177, R 2 =0.385; LUSC: y=0.965x+9.318, R 2 =0.198). (G) The Oncomine datasets for the corresponding YTHDC2 copy numbers in lung cancer were obtained with a threshold P=0.001 and ≥2 fold-change. The data in the graphic show significant downregulation (blue column) of YTHDC2 copy numbers in lung cancer versus normal tissue. The intensity of the blue color represents the respective levels of YTHDC2 copy number. (H) Copy number variation in LUAD samples with different smoking histories. Different letters (a, b, c and d) represent statistically significant group differences. (I) Copy number variation of YTHDC2 in BEAS-2B cells and cigarette smoke-exposed cells (grey block), as well as in two lung cancer cell lines (black block). The dotted line (copy number = 2) represents the copy number of the reference gene RNase P. * P<0.05, ** P<0.01 vs. BEAS-2B cells. YTHDC2, YTH domain containing 2; LUSC, lung squamous cell carcinoma; LUAD , lung adenocarcinoma.

    Article Snippet: Human lung cancer tissue arrays (cat. no. LAC-1402 and LAC-1403) were purchased from Wuhan Servicebio Technology Co., Ltd.

    Techniques: Expressing, Amplification, Blocking Assay